Ethanol → HCID 67288335, compound

Participants

Reaction Steps

Ethyl 6-chloro-7-(4-(5-phenyl-1,3,4-thiadiazol-2-ylcarbamoyl)phenoxy)chroman-4-carboxylate (17 mg, 0.032 mmol) was diluted with THF (500 μL) followed by the addition of NaOH (159 μL, 0.16 mmol) and ethanol (200 μL). After stirring for 4 hours, the reaction was diluted with ethyl acetate and 1N HCl, the layers were separated and the organic layer was dried over MgSO4, filtered and concentrated. The material was purified using a 0.5 mm preparative TLC plate eluting with 10% methanol/DCM to yield the desired compound (5 mg, 0.0098 mmol, 31% yield). MS (ESI)=508.1 (M+1).

Provenance & Evidence