Hydrochloric Acid → HCID 86664396, compound

Participants

Reaction Steps

Ethyl 7-(4-(4-tert-butylthiazol-2-ylcarbamoyl)phenoxy)-6-chlorochroman-4-carboxylate (408 μl, 0.0408 mmol) in 2:1 THF-Ethanol was treated with 1N sodium hydroxide (0.061 ml, 0.061 mmol) at ambient temperature. After 18 hours, the reaction was diluted with ethyl acetate and acidified with hydrogen chloride (81.6 μl, 0.0816 mmol). The reaction was washed with brine, dried with sodium sulfate, filtered, and concentrated in vacuo to give the desired product (0.015 g, 76%) as a white solid. MS (APCI)=487.1 (M+1).

Provenance & Evidence