Sulfuric Acid → HCID 21812830, compound

Participants

Reaction Steps

N-(1-(3-chlorophenyl)-1H-pyrazol-4-yl)benzamide (1.34 g, 4.5 mmol) was heated with 68% sulfuric acid (24 mL) at 100° C. for 2 hours and then at 110° C. for 3 hours. The reaction was diluted with water (100 mL) and basified with sodium hydroxide solution. The aqueous mixture was extracted with ethyl acetate. The combined extracts were dried (sodium sulfate), filtered and evaporated. The solid were dried under high vacuum to provide the title compound (0.82 g; 94%) as a brown solid.

Provenance & Evidence