Sodium Methoxide → HCID 67288796, compound

Participants

Reaction Steps

6-chloro-7-(4-(1-(3-chlorophenyl)-1H-pyrazol-4-ylcarbamoyl)phenoxy)chroman-4-carboxylic acid (250 mg, 0.48 mmol) was dissolved in methanol (5 ml) and treated with 0.5 N sodium methoxide in methanol (0.954 ml, 0.48 mmol) at ambient temperature. After 30 minutes, the reaction was concentrated in vacuo, triturated with ethyl acetate and hexanes, and dried under high vacuum to provide the title compound (240 mg, 92%) as a white solid. MS (apci)=526.0 (M-Na+2H)

Provenance & Evidence