2-Amino-6-bromopyridine → HCID 178521756, compound

HRID 1626504Notes

Reaction equation

HRID 1626504 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][C:13]1[CH:21]=[CH:20][C:16]([C:17]([OH:19])=O)=[CH:15][CH:14]=1)[O:8][CH2:7][CH2:6][CH:5]2[C:22]([O:24]CC)=[O:23].BrC1N=C(N)C=CC=1.[Cl:35][C:36]1[CH:41]=[CH:40][C:39]([C:42]2[CH:46]=[C:45]([NH2:47])[NH:44][N:43]=2)=[CH:38][CH:37]=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][C:13]1[CH:21]=[CH:20][C:16]([C:17](=[O:19])[NH:47][C:45]3[NH:44][N:43]=[C:42]([C:39]4[CH:40]=[CH:41][C:36]([Cl:35])=[CH:37][CH:38]=4)[CH:46]=3)=[CH:15][CH:14]=1)[O:8][CH2:7][CH2:6][CH:5]2[C:22]([OH:24])=[O:23]

Participants

4

Reactant 3

HCID 3008092-Amino-6-bromopyridineHCID 582443954-(6-Chloro-4-(ethoxycarbonyl)chroman-7-yloxy)benzoic acidHCID 178507284HCID 178507284, compound

Product 1

HCID 178521756HCID 178521756, compound

Procedure

Prepared according to the method of Example 39, substituting 4-(6-cyano-4-(methoxycarbonyl)chroman-7-yloxy)benzoic acid in Step A with 4-(6-chloro-4-(ethoxycarbonyl)chroman-7-yloxy)benzoic acid and 6-bromopyridin-2-amine with 3-(4-chlorophenyl)-1H-pyrazol-5-amine. MS (apci) m/z=524.1 (M+H).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-fc1e5229d0674f8bb7652cf5b0f0e887
Source dataset
uspto-grants-2014_07
Patent number
US08785445B2

Reaction notes

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