Nitromethane → HCID 67288800, compound

Participants

Reaction Steps

6-Cyclopropyl-2-methoxynicotinaldehyde (121 mg, 0.683 mmol) was diluted with nitromethane (259 μL, 4.78 mmol) followed by the addition of methylamine hydrochloride (27.7 mg, 0.410 mmol) and sodium acetate (33.6 mg, 0.410 mmol). After stirring for 4 hours, the reaction was loaded directly onto a silica gel column and eluted with 5% ethyl acetate/hexanes to 50% ethyl acetate hexanes to yield (E)-6-cyclopropyl-2-methoxy-3-(2-nitrovinyl)pyridine (135 mg, 0.613 mmol, 89.8% yield).

Provenance & Evidence