Sodium Methoxide → HCID 67289561, compound

Participants

Reaction Steps

6-Chloro-7-(4-(2-(6-cyclopropyl-2-methoxypyridin-3-yl)ethylcarbamoyl)phenoxy)chroman-4-carboxylic acid (70 mg, 0.13 mmol) was diluted with methanol (1 mL) followed by the addition of NaOMe (268 μL, 0.13 mmol). After stirring for 2 hours, the reaction was concentrated and dried under high vacuum pressure for 2 hours. The material was diluted with hexanes, sonicated and concentrated to afford 6-chloro-7-(4-(2-(6-cyclopropyl-2-methoxypyridin-3-yl)ethylcarbamoyl)phenoxy)chroman-4-carboxylic acid sodium salt (40 mg, 0.076 mmol, 57% yield). MS (es+apci, positive) m/z=523.2.]

Provenance & Evidence