Trifluoroacetic acid → HCID 66687855, compound

Participants

Reaction Steps

To a stirred solution of (S)-tert-butyl 2-(4-(3-cyclopropylureido)phenyl)-4-(3-methylmorpholino)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate (3.27 g, 6.43 mmol) in DCM (40 mL) was added TFA (20 mL). The reaction mixture was stirred at room temperature for 2 h. The mixture was concentrated and the resulting residue was dissolved in the minimum MeOH and precipitated from Et2O to give a pale yellow solid (498 mg, 0.95 mmol, 15% yield).

Provenance & Evidence