反应详情

To a solution of (S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea (example 3) (50 mg 0.13 mmol) in dioxane (3 mL) at room temperature (20° C.) was added ethyl isocyanate (20 uL 0.26 mmol). The reaction mixture was stirred for 16 h. The solvent was removed in vacuo and the solid residue triturated with ether. The solid was collected by filtration and dried in vacuo to afford (32 mg 55%).

1. customThe solvent was removed in vacuo
2. customthe solid residue triturated with ether
3. filtrationThe solid was collected by filtration
4. customdried in vacuo
5. customto afford (32 mg 55%)