N,N-Dimethylethylenediamine → (S)-1-(2-(dimethylamino)ethyl)-3-(4-(6-methyl-4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea

Participants

Role	Name	HCID	Charge
Reactant	N,N-Dimethylethylenediamine	HCID 66053	—
Reactant	(S)-phenyl 4-(6-methyl-4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenylcarbamate	HCID 66678768	—
Product	(S)-1-(2-(dimethylamino)ethyl)-3-(4-(6-methyl-4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea	HCID 46912598	—

Reaction Steps

Method as described for example 51 using intermediate 10 and N1,N1-dimethylethane-1,2-diamine as starting materials. Purified by prep. LCMS (high pH).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08785457B2
Source dataset	uspto-grants-2014_07
ORD ID	ord-7e8ae36a0b74423ca74d70416980bf33
Source note	uspto-grants-2014_07