Cyclopropanecarbonyl chloride → HCID 46912705, compound

Participants

Reaction Steps

To a stirred solution of (S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea 2,2,2-trifluoroacetate (106 mg, 0.26 mmol) in DCM was added iPr2NEt (91 uL, 0.52 mmol) and cyclopropane carbonyl chloride (26 uL, 0.29 mmol). The reaction mixture was stirred at room temperature for 16 h. The reaction mixture was concentrated and triturated from Et2O:MeOH (10:1) to give a white solid (69 mg, 0.15 mmol, 58% yield).

Provenance & Evidence