反应详情

Method as described for intermediate 5 using 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline as starting material. The crude reaction mixture was filtered through a celite 545 pre-packed cartridge (2.5 g), washed with MeOH and solvent removed in vacuo. The residue was purified by flash SCX2 chromatography affording the title compound (139 mg, 0.40 mmol, 98%).

1. customThe crude reaction mixture
2. filtrationwas filtered through a celite 545 pre-packed cartridge (2.5 g)
3. washwashed with MeOH and solvent
4. customremoved in vacuo
5. customThe residue was purified by flash SCX2 chromatography