Isobutyraldehyde → (S)-1-cyclopropyl-3-(4-(6-isobutyl-4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea

Participants

Role	Name	HCID	Charge
Reactant	Isobutyraldehyde	HCID 6561	—
Reactant	(S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea	HCID 46894114	—
Product	(S)-1-cyclopropyl-3-(4-(6-isobutyl-4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea	HCID 46912975	—

Reaction Steps

Method as described for example 26 using (S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea (example 3) and iso-butyraldehyde as starting materials. Purified by prep HPLC (low pH).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08785457B2
Source dataset	uspto-grants-2014_07
ORD ID	ord-94b09b8429a14256adb38375d7703152
Source note	uspto-grants-2014_07