Isobutyraldehyde → HCID 46912887, compound

HRID 1626583Notes

Reaction equation

HRID 1626583 reaction equation
[CH2:1]([NH:3][C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]=[C:15]([N:22]3[CH2:27][CH2:26][O:25][CH2:24][C@@H:23]3[CH3:28])[C:16]3[CH2:21][NH:20][CH2:19][C:17]=3[N:18]=2)=[CH:9][CH:8]=1)=[O:5])[CH3:2].[CH:29](=O)[CH:30]([CH3:32])[CH3:31]>>[CH2:1]([NH:3][C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]=[C:15]([N:22]3[CH2:27][CH2:26][O:25][CH2:24][C@@H:23]3[CH3:28])[C:16]3[CH2:21][N:20]([CH2:29][CH:30]([CH3:32])[CH3:31])[CH2:19][C:17]=3[N:18]=2)=[CH:9][CH:8]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 6561IsobutyraldehydeHCID 46913468HCID 46913468, compound

Product 1

HCID 46912887HCID 46912887, compound

Procedure

Method as described for example 26 using (S)-1-ethyl-3-(4-(4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea (example 7) and iso-butyraldehyde as starting materials. Purified by prep HPLC (low pH).

Workup

  1. customPurified by prep HPLC (low pH)

Sources & evidence

ORD record
ord-16158ea5a84149438199c9248764d8fd
Source dataset
uspto-grants-2014_07
Patent number
US08785457B2

Reaction notes

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