Acetone → HCID 46912977, compound

HRID 1626591Notes

Reaction equation

HRID 1626591 reaction equation
[CH2:1]([NH:3][C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]=[C:15]([N:22]3[CH2:27][CH2:26][O:25][CH2:24][C@@H:23]3[CH3:28])[C:16]3[CH2:21][NH:20][CH2:19][C:17]=3[N:18]=2)=[CH:9][CH:8]=1)=[O:5])[CH3:2].[CH3:29][C:30]([CH3:32])=O>>[CH2:1]([NH:3][C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]=[C:15]([N:22]3[CH2:27][CH2:26][O:25][CH2:24][C@@H:23]3[CH3:28])[C:16]3[CH2:21][N:20]([CH:30]([CH3:32])[CH3:29])[CH2:19][C:17]=3[N:18]=2)=[CH:9][CH:8]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 180AcetoneHCID 46913468HCID 46913468, compound

Product 1

HCID 46912977HCID 46912977, compound

Procedure

Method as example 26 using (S)-1-ethyl-3-(4-(4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea (example 7) and acetone as starting materials. Purification by prep HPLC (high pH).

Workup

  1. customPurification by prep HPLC (high pH)

Sources & evidence

ORD record
ord-68008eba8aea4d7183dc394c7bb57e7c
Source dataset
uspto-grants-2014_07
Patent number
US08785457B2

Reaction notes

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