Trifluoroacetic acid → HCID 46913172, compound

Participants

Reaction Steps

To a solution of (S)-ethyl 2-(4-(3-ethylureido)phenyl)-4-(3-methylmorpholino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate trifluoroacetate (example 7 as a trifluoroacetic acid salt) (155 mg, 0.25 mmol) in dioxane (4 mL) at room temperature (20° C.) was added DIPEA (22 uL, 0.26 mmol) followed by ethyl chloroformate (24 uL, 0.25 mmol). The reaction mixture was stirred for 3 h. The solvent was removed in vacuo and the residue purified by prep HPLC (low pH) to afford a brown solid (36 mg, 32%).

Provenance & Evidence