反应详情

The product from step 1 was treated as described for example 85 with ethyl isocyanate. The mixture was concentrated in vacuo and the material purified by prep HPLC at high and low pH, yielding the title compound (15.5 mg, 0.037 mmol, 11% over 2 steps).

1. concentrationThe mixture was concentrated in vacuo
2. customthe material purified by prep HPLC at high and low pH