反应详情

Step 1 Method as described for intermediate 5 using (S)-ethyl 2-chloro-4-(3-methylmorpholino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate (intermediate 11) and 3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline as starting materials. The mixture was filtered through a celite 545 pre-packed cartridge (2.5 g), washed with MeOH and solvent removed in vacuo. The residue was purified by prep HPLC (high pH) yielding the title compound (54.7 mg, 0.13 mmol, 44%).

1. filtrationThe mixture was filtered through a celite 545 pre-packed cartridge (2.5 g)
2. washwashed with MeOH and solvent
3. customremoved in vacuo
4. customThe residue was purified by prep HPLC (high pH)