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HRID1626627

反应详情

EQUATION

反应方程式

HRID 1626627 的结构方程式

REACTANTS

反应物

2
结构：CCN=C=O
HCID8022

Ethyl isocyanate

C3H5NO

结构：CCOC(=O)N1Cc2nc(-c3ccc(N)cc3F)nc(N3CCOC[C@@H]3C)c2C1
HCID66679046

未命名化合物

PRODUCTS

生成物

1
结构：CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CN(C(=O)OCC)C3)c(F)c1
HCID66679040

未命名化合物

收率 34%

PROCEDURE

实验过程

Method as example 85 using (S)-ethyl 2-(4-amino-2-fluorophenyl)-4-(3-methylmorpholino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate and ethyl isocyanate as starting materials. The solvent was removed in vacuo and purified by prep HPLC (low pH) yielding the title compound (14.6 mg, 0.03 mmol, 34%).

WORKUP

后处理

  1. customThe solvent was removed in vacuo
  2. custompurified by prep HPLC (low pH)