Dimethylformamide → HCID 66678956, compound

Participants

Reaction Steps

To a solution of (S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea (Example 3) (100 mg, 0.37 mmol) and triethyamine (42.4 μL, 0.30 mmol) in DCM (3 mL, anhydrous), and DMF (1 mL, anhydrous) was added tetrahydro-2H-pyran-4-carbonyl chloride (45.2 mg, 0.30 mmol). The reaction mixture was stirred at room temperature until LCMS indicated reaction was complete. Solvent was then removed in vacuo.

Provenance & Evidence