3-[acetyl(methyl)amino]propanoic acid → HCID 46913365, compound

HRID 1626648Notes

Reaction equation

HRID 1626648 reaction equation
[CH3:1][N:2]([CH2:6][CH2:7][C:8]([OH:10])=O)[C:3](=[O:5])[CH3:4].[CH:11]1([NH:14][C:15]([NH:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]3[N:25]=[C:26]([N:33]4[CH2:38][CH2:37][O:36][CH2:35][C@@H:34]4[CH3:39])[C:27]4[CH2:32][NH:31][CH2:30][C:28]=4[N:29]=3)=[CH:20][CH:19]=2)=[O:16])[CH2:13][CH2:12]1>>[CH:11]1([NH:14][C:15](=[O:16])[NH:17][C:18]2[CH:19]=[CH:20][C:21]([C:24]3[N:25]=[C:26]([N:33]4[CH2:38][CH2:37][O:36][CH2:35][C@@H:34]4[CH3:39])[C:27]4[CH2:32][N:31]([C:8](=[O:10])[CH2:7][CH2:6][N:2]([CH3:1])[C:3](=[O:5])[CH3:4])[CH2:30][C:28]=4[N:29]=3)=[CH:22][CH:23]=2)[CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 5415803-[acetyl(methyl)amino]propanoic acidHCID 46894114(S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea

Product 1

HCID 46913365HCID 46913365, compoundYield 26%

Procedure

Method as example 127 using 3-(N-methylacetamido)propanoic acid and (S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea (example 3) as starting materials to yield a white solid (36.8 mg, 0.071 mmol, 26%).

Sources & evidence

ORD record
ord-0cea2761a34b42469d81ae3b4ccc52e5
Source dataset
uspto-grants-2014_07
Patent number
US08785457B2

Reaction notes

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