N-carbamoyl-beta-alanine → HCID 46913366, compound

HRID 1626649Notes

Reaction equation

HRID 1626649 reaction equation
[NH:1]([CH2:5][CH2:6][C:7]([OH:9])=O)[C:2]([NH2:4])=[O:3].[CH:10]1([NH:13][C:14]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]3[N:24]=[C:25]([N:32]4[CH2:37][CH2:36][O:35][CH2:34][C@@H:33]4[CH3:38])[C:26]4[CH2:31][NH:30][CH2:29][C:27]=4[N:28]=3)=[CH:19][CH:18]=2)=[O:15])[CH2:12][CH2:11]1>>[CH:10]1([NH:13][C:14]([NH:16][C:17]2[CH:18]=[CH:19][C:20]([C:23]3[N:24]=[C:25]([N:32]4[CH2:37][CH2:36][O:35][CH2:34][C@@H:33]4[CH3:38])[C:26]4[CH2:31][N:30]([C:7](=[O:9])[CH2:6][CH2:5][NH:1][C:2]([NH2:4])=[O:3])[CH2:29][C:27]=4[N:28]=3)=[CH:21][CH:22]=2)=[O:15])[CH2:11][CH2:12]1

Participants

3

Reactant 2

HCID 111N-carbamoyl-beta-alanineHCID 46894114(S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea

Product 1

HCID 46913366HCID 46913366, compound

Procedure

Method as example 127 using 3-ureidopropanoic acid and (S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea (example 3) as starting materials to afford a white solid (22.3 mg, 0.044 mmol, 16%.

Workup

  1. customto afford a white solid (22.3 mg, 0.044 mmol, 16%

Sources & evidence

ORD record
ord-8d1e796e5ae2448bbde6bad9ff5f7a78
Source dataset
uspto-grants-2014_07
Patent number
US08785457B2

Reaction notes

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