反应详情

Prepared as 1-ethyl-3-(3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea (intermediate 28) using 3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline and cyclopropyl isocyanate as starting materials. The crude reaction mixture was then partitioned between DCM and water. The organic layer was recovered, passed through a hydrophobic frit and the solvent removed in vacuo to yield a light orange solid (3.2 g, 10 mmol, 100%).

1. customThe crude reaction mixture
2. customwas then partitioned between DCM and water
3. customThe organic layer was recovered
4. customthe solvent removed in vacuo