Dimethylcarbamoyl Chloride → HCID 66679239, compound

Participants

Reaction Conditions

Reaction Steps

To a stirring solution of (S)-1-cyclopropyl-3-(3-fluoro-4-(4-(3-methylmorpholino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea (example 163) (99 mg, 0.23 mmol) and NEt3 (35 μL, 0.25 mmol) in DMF (2 ml) was added dimethylcarbamoyl chloride (29 μL, 0.25 mmol). Reaction mixture was stirred at room temperature (20° C.) overnight before being concentrated in vacuo and purified by prep. HPLC at high pH to afford a white solid (42 mg, 37%).

Provenance & Evidence