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HRID1626695

反应详情

EQUATION

反应方程式

HRID 1626695 的结构方程式

REACTANTS

反应物

2
结构：COC(=O)N1Cc2nc(Cl)nc(N3CCOCC3)c2C1
HCID86663169

未命名化合物

2 次

结构：CCOC(=O)N1Cc2nc(-c3ccc(NC(=O)NCCF)cc3F)nc(N3CCOC[C@@H]3C)c2C1
HCID86663175

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)N1Cc2nc(-c3ccc(NC(=O)NCCF)cc3F)nc(N3CCOCC3)c2C1
HCID86663176

未命名化合物

收率 16%

PROCEDURE

实验过程

Method as (S)-Ethyl 2-(2-fluoro-4-(3-(2-fluoroethyl)ureido)phenyl)-4-(3-methylmorpholino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate (Example 168) using methyl 2-chloro-4-morpholino-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate (intermediate 25). Residue was then purified by prep. HPLC at low pH to afford a colourless solid (16%).

WORKUP

后处理

  1. customResidue was then purified by prep