Isopropyl isocyanate → HCID 66679251, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of (S)-1-cyclopropyl-3-(3-fluoro-4-(4-(3-methylmorpholino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea (Example 163) (100 mg, 0.23 mmol) in DMF (2 ml) was added isopropyl isocyanate (35 μl, 0.35 mmol). Reaction mixture was stirred at 20° C. for 2 hours. The crude reaction mixture was then partitioned between water (10 ml) and DCM (10 ml). The organic layer was recovered, passed through a hydrophobic frit and the solvent removed in vacuo. Residue was then purified by prep. HPLC at high pH to afford the title compound as a white solid (61 mg, 0.12 mmol, 52%)

Provenance & Evidence