Hydrochloric Acid → HCID 46935551, compound

Participants

Reaction Conditions

Reaction Steps

3 mL of THF and 1.2 mL of 1N aqueous sodium hydroxide were added to 0.30 g (0.81 mmol) of methyl 5-chloro-2-({[3-(furan-3-yl)phenyl]acetyl}amino)benzoate at room temperature, and the mixture was stirred at 50° C. for 2.5 hours. After cooling, 1N hydrochloric acid was added to acidify the reaction mixture. Thereafter, the solvent was distilled off under reduced pressure, and water was then added to the residue. Solids were collected by filtration, followed by drying, thereby giving 252 mg of the target 5-chloro-2-({[3-(furan-3-yl)phenyl]acetyl}amino)benzoic acid (yield: 88%).

Provenance & Evidence