Carbon Dioxide → HCID 46935552, compound

Participants

Reaction Steps

433 mg (1.0 mmol) of N-(4-chloro-2-iodophenyl)biphenyl-3-carboxamide was dissolved in 5 mL of THF solution, and 1.6M n-butyllithium(n-BuLi)hexane solution (1.25 mL) was added dropwise under an Ar atmosphere at −78° C. The mixture was stirred for 0.5 hours. Dry ice was added thereto, and the mixture was stirred at room temperature for 2 hours. The reaction mixture was diluted with ethyl acetate, washed with 1N hydrochloric acid and saturated saline, and dried over anhydrous sodium sulfate. The resultant was separated and purified by silica gel column chromatography, thereby giving 48.2 mg of the target 2-[(biphenyl-3-ylcarbonyl)amino]-5-chlorobenzoic acid (yield: 14%).

Provenance & Evidence