Trifluoroacetic acid → HCID 46935553, compound

Participants

Reaction Steps

0.5 g (1.2 mmol) of tert-butyl 2-({[3-(furan-3-yl)phenyl]carbonyl}amino)-5-methyl-4-phenylthiophene-3-carboxylate was dissolved in 2 mL of chloroform, and 5 mL of trifluoroacetic acid (TFA) was added thereto at 0° C. The mixture was stirred at room temperature for 5 hours. n-hexane was added to the reaction mixture, and solids were collected by filtration, followed by recrystallization using a mixed solvent of ethyl acetate and n-hexane, thereby giving 0.34 g of the target 2-({[3-(furan-3-yl)phenyl]carbonyl}amino)-5-methyl-4-phenylthiophene-3-carboxylic acid (yield: 70%).

Provenance & Evidence