Hydrogen chloride-ethyl acetate → HCID 66680322, compound

Participants

Reaction Steps

4N hydrogen chloride/ethyl acetate (10 mL) was added to an ethyl acetate (10 mL) solution comprising 1.40 g (3.66 mmol) of tert-butyl (2S)-2-{[4-chloro-2-(methoxycarbonyl)phenyl]carbamoyl}pyrrolidine-1-carboxylate at 0° C., and the mixture was stirred at room temperature for 5 hours. After the reaction mixture was condensed, IPE was added to the residue, and white solids were collected by filtration, washed with IPE, and dried under reduced pressure at room temperature, thereby giving 1.15 g of methyl 5-chloro-2-(L-prolylamino)benzoate hydrochloride (yield: 98%).

Provenance & Evidence