Dimethylacetamide → HCID 86661492, compound

Participants

Reaction Steps

Under ice-cooling, 660 mg (3.56 mmol) of methyl 2-amino-5-chlorobenzoate was added to a DMAc (10 mL) solution comprising 1.00 g (3.62 mmol) of 3,5-bis(trifluoromethyl)benzoyl chloride, and the mixture was stirred at room temperature for 5 hours. Water was added to the reaction mixture, and the mixture was stirred for a short time. Thereafter, the precipitates were collected by filtration, washed with water, and then air-dried, thereby giving methyl 2-({[3,5-bis(trifluoromethyl)phenyl]carbonyl}amino)-5-chlorobenzoate (yield: 99%).

Provenance & Evidence