Sodium Hydroxide → HCID 66680639, compound

Participants

Reaction Steps

10 mL of THF and 1.3 mL of 1N aqueous sodium hydroxide solution were added to 340 mg (0.816 mmol) of methyl 5-chloro-2-({[3-(quinolin-3-yl)phenyl]carbonyl}amino)benzoate, and the mixture was stirred at room temperature for 1 day. The mixture was further stirred at 50° C. for 1 hour. THF was distilled off under reduced pressure, and water was added. Water-washing was then conducted, thereby giving 360 mg of the target sodium 5-chloro-2-({[3-(quinolin-3-yl)phenyl]carbonyl}amino)benzoate (yield: 77%).

Provenance & Evidence