Methyl 2-amino-5-chlorobenzoate → HCID 66680117, compound

HRID 1626769Notes

Reaction equation

HRID 1626769 reaction equation
[C:1]1([C:7]2[O:11][C:10]([C:12]([OH:14])=O)=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:15][C:16]1[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][C:17]=1[C:18]([O:20]C)=[O:19]>>[Cl:26][C:23]1[CH:24]=[CH:25][C:16]([NH:15][C:12]([C:10]2[O:11][C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[CH:8][CH:9]=2)=[O:14])=[C:17]([CH:22]=1)[C:18]([OH:20])=[O:19]

Participants

3

Reactant 2

HCID 78878Methyl 2-amino-5-chlorobenzoateHCID 7362555-Phenylfuran-2-carboxylic acid

Product 1

HCID 66680117HCID 66680117, compoundYield 77%

Procedure

Using the same method as in Example 3-(i), methyl 5-chloro-2-{[(5-phenylfuran-2-yl)carbonyl]amino}benzoate was obtained using 5-phenylfuran-2-carboxylic acid and methyl 2-amino-5-chlorobenzoate. Thereafter, using the same method as in Example 3-(ii), the target 5-chloro-2-{[(5-phenylfuran-2-yl)carbonyl]amino}benzoic acid was obtained (yield: 77%).

Sources & evidence

ORD record
ord-a42d2c43c3bd42dab4d00411335090cb
Source dataset
uspto-grants-2014_07
Patent number
US08785473B2

Reaction notes

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