HCID 68196361, compound → HCID 68196362, compound

Participants

Reaction Steps

Ethyl({[5-(benzyloxy)-2-({1-[4′-(hydroxymethyl)biphenyl-4-yl]piperidin-4-yl}methyl)-6-methylpyrimidin-4-yl]carbonyl}amino)acetate (0.43 g, 0.71 mmol) was dissolved in a mixed solvent of ethyl acetate (20 mL) and dichloromethane (20 mL), and 10% palladium-activated carbon (0.080 g) was added, followed by stirring at room temperature for 2.5 hours under a hydrogen atmosphere. The reaction solution was filtered with celite, and the filtrate was concentrated under reduced pressure, whereby a solid was deposited. The resulting solid was collected by filtration, and dried under reduced pressure to afford the title compound (0.34 g, 0.66 mmol) as a white solid (yield 93%).

Provenance & Evidence