Sodium Hydroxide → HCID 52937955, compound

Participants

Reaction Steps

Ethyl({[5-hydroxy-2-({1-[4′-(hydroxymethyl)biphenyl-4-yl]piperidin-4-yl}methyl)-6-methylpyrimidin-4-yl]carbonyl}amino)acetate (0.22 g, 0.42 mmol) was dissolved in a mixed solvent of methanol (5 mL) and tetrahydrofuran (5 mL), and an aqueous sodium hydroxide solution (1 M, 5.0 mL) was added, followed by stirring at room temperature for 30 minutes. The reaction solution was concentrated under reduced pressure, and hydrochloric acid (1 M, 5.0 mL) was added to the resulting residue, whereby a solid was deposited. The resulting solid was collected by filtration, and dried under reduced pressure to afford the title compound (0.17 g, 0.35 mmol) as a pale yellowish white solid (yield 82%).

Provenance & Evidence