(4-Bromophenyl)boronic acid → HCID 68193265, compound

Participants

Reaction Steps

tert-Butyl[2-(4-iodophenyl)ethoxy]dimethylsilane (7.1 g, 19.6 mmol), (4-bromophenyl)boronic acid (4.8 g, 23.9 mmol), tripotassium phosphate n-hydrate (10.4 g, 49.0 mmol) and a [1,1′-bis(diphenylphosphino)ferrocene]palladium dichloride dichloromethane complex (0.80 g, 0.98 mmol) were suspended in 1,2-dimethoxyethane (150 mL), followed by stirring at room temperature for 4 hours under a nitrogen atmosphere. After the reaction solution was filtered with celite, the filtrate was concentrated under reduced pressure. The resulting residue was purified by chromatography on a silica gel column (Moritex Corporation, elution solvent: hexane), and a fraction corresponding to the Rf value=0.90 (hexane/ethyl acetate=19/1) by thin layer chromatography was concentrated under reduced pressure to afford the title compound (2.0 g, 5.1 mmol) as a white solid (yield 26%).

Provenance & Evidence