Water → HCID 68193215, compound

Participants

Reaction Steps

Ethyl 2-(4′-bromobiphenyl-4-yl)-2-methylpropionate (6.2 g, 18 mmol) was dissolved in tetrahydrofuran (150 mL), and lithium aluminum hydride (0.68 g, 18 mmol) was added at 0° C., followed by stirring at the same temperature for 1.5 hours. Water was added to the reaction solution, and the insolubles were filtered with celite, followed by extraction with ethyl acetate. After the solvent was distilled off under reduced pressure, the resulting residue was purified by chromatography on a silica gel column (Moritex Corporation, elution solvent: hexane/ethyl acetate), and a fraction corresponding to the Rf value=0.40 (hexane/ethyl acetate=1/1) by thin layer chromatography was concentrated under reduced pressure to afford the title compound (5.0 g, 16 mmol) as a white solid (yield 92%).

Provenance & Evidence