Chloromethyl Methyl Ether → HCID 68193206, compound

Participants

Reaction Steps

2-(4′-Bromobiphenyl-4-yl)-2-methylpropan-1-ol (5.0 g, 16 mmol) was dissolved in toluene (40 mL), and chloromethyl methyl ether (2.5 mL, 33 mmol) and N,N-diisopropylethylamine (3.6 mL, 21 mmol) were added, followed by stirring at room temperature for 17 hours. After the reaction solution was diluted with ethyl acetate, the organic layer was washed with water. After the solvent was distilled off under reduced pressure, the resulting residue was purified by chromatography on a silica gel column (Moritex Corporation, elution solvent: hexane/ethyl acetate), and a fraction corresponding to the Rf value=0.45 (hexane/ethyl acetate=10/1) by thin layer chromatography was concentrated under reduced pressure to afford the title compound (5.8 g, 16 mmol) as a white solid (yield 100%).

Provenance & Evidence