Hydrochloric Acid → HCID 68196368, compound

Participants

Reaction Steps

Benzyl({[5-(benzyloxy)-2-{[1-(4-{5-[1-(methoxymethoxy)ethyl]pyridin-2-yl}phenyl)piperidin-4-yl]methyl}-6-methylpyrimidin-4-yl]carbonyl}amino)acetate (0.80 g, 1.1 mmol) was dissolved in ethyl acetate (6 mL), and a solution of hydrogen chloride in dioxane (4 M, 1.5 mL, 6.0 mmol) was added, followed by stirring at room temperature for 1.5 hours. After hexane was added to the reaction solution, the deposited solid was collected by filtration using hexane. To this, was added a saturated aqueous sodium hydrogencarbonate solution, followed by extraction with ethyl acetate, and subsequently the organic layer was concentrated under reduced pressure. The resulting residue was purified by chromatography on a silica gel column (Moritex Corporation, elution solvent: hexane/ethyl acetate), and a fraction corresponding to the Rf value=0.30 (hexane/ethyl acetate=1/1) by thin layer chromatography was concentrated under reduced pressure to afford the title compound (0.32 g, 0.49 mmol) as a yellow solid (yield 44%).

Provenance & Evidence