HCID 68196368, compound → HCID 52932119, compound

Participants

Reaction Steps

Benzyl [({5-(benzyloxy)-2-[(1-{4-[5-(1-hydroxyethyl)pyridin-2-yl]phenyl}piperidin-4-yl)methyl]-6-methylpyrimidin-4-yl}carbonyl)amino]acetate (0.10 g, 0.16 mmol) was dissolved in ethyl acetate (30 mL), and 10% palladium-activated carbon (0.25 g) was added, followed by stirring at room temperature for 9 hours under a hydrogen atmosphere. After the reaction solution was filtered with celite, the filtrate was concentrated under reduced pressure. The resulting residue was purified by chromatography on a silica gel column (Moritex Corporation, elution solvent: ethyl acetate/methanol), and a fraction corresponding to the Rf value=0.10 (ethyl acetate/methanol=4/1) by thin layer chromatography was concentrated under reduced pressure to afford the title compound (0.045 g, 0.089 mmol) as a yellow solid (yield 56%).

Provenance & Evidence