(4-Bromophenyl)boronic acid → HCID 24729901, compound

HRID 1626801Notes

Reaction equation

HRID 1626801 reaction equation
Br[C:2]1[N:7]=[CH:6][C:5]([CH2:8][OH:9])=[CH:4][CH:3]=1.[Br:10][C:11]1[CH:16]=[CH:15][C:14](B(O)O)=[CH:13][CH:12]=1>>[Br:10][C:11]1[CH:16]=[CH:15][C:14]([C:2]2[N:7]=[CH:6][C:5]([CH2:8][OH:9])=[CH:4][CH:3]=2)=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 79599(4-Bromophenyl)boronic acidHCID 64212496-Bromo-3-pyridinemethanol

Product 1

HCID 24729901HCID 24729901, compound

Procedure

In accordance with Example 11-(1), but using (6-bromopyridin-3-yl)methanol instead of 4-bromobenzyl bromide, and 4-bromophenylboronic acid instead of [3-(hydroxymethyl)phenyl]boronic acid, [6-(4-bromophenyl)pyridin-3-yl]methanol was afforded as a white solid (yield 51%).

Sources & evidence

ORD record
ord-9178c0f6b425431bb53b5bebd28a556a
Source dataset
uspto-grants-2014_07
Patent number
US08785462B2

Reaction notes

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