Trifluoroacetic acid → HCID 68193221, compound

Participants

Reaction Steps

tert-Butyl 5-(benzyloxy)-2-[(1-{4-[5-(ethoxycarbonyl)pyridin-2-yl]phenyl}piperidin-4-yl)methyl]-6-methylpyrimidine-4-carboxylate (0.25 g, 0.40 mmol) was dissolved in dichloromethane (5 mL), and trifluoroacetic acid (10 mL) was added, followed by stirring at room temperature for 12 hours. The reaction solution was concentrated under reduced pressure, and a saturated aqueous sodium hydrogencarbonate solution was added, followed by extraction with ethyl acetate. After the organic layer was dried over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure to afford 2-[(1-{4-[5-(ethoxycarbonyl)pyridin-2-yl]phenyl}piperidin-4-yl)methyl]-5-hydroxy-6-methylpyrimidine-4-carboxylic acid.

Provenance & Evidence