4-(Hydroxymethyl)benzeneboronic acid → HCID 68193230, compound

HRID 1626811Notes

Reaction equation

HRID 1626811 reaction equation
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6](B(O)O)=[CH:5][CH:4]=1.[Br:12][C:13]1[CH:18]=[CH:17][C:16](I)=[C:15]([Cl:20])[CH:14]=1>>[Br:12][C:13]1[CH:18]=[CH:17][C:16]([C:6]2[CH:7]=[CH:8][C:3]([CH2:2][OH:1])=[CH:4][CH:5]=2)=[C:15]([Cl:20])[CH:14]=1

Participants

3

Reactant 2

HCID 27347064-(Hydroxymethyl)benzeneboronic acidHCID 27355474-Bromo-2-chloro-1-iodobenzene

Product 1

HCID 68193230HCID 68193230, compoundYield 12%

Procedure

In accordance with Example 4-(2), but using [4-(hydroxymethyl)phenyl]boronic acid instead of 4-bromophenylboronic acid, and 4-bromo-2-chloro-1-iodobenzene instead of tert-butyl[2-(4-iodophenyl)ethoxy]dimethylsilane, the title compound (yield 12%) was afforded as a yellow solid.

Sources & evidence

ORD record
ord-22167a1a3d6f47168b89030ca0567873
Source dataset
uspto-grants-2014_07
Patent number
US08785462B2

Reaction notes

Loading…