(4-Bromophenyl)boronic acid → HCID 68193339, compound

HRID 1626815Notes

Reaction equation

HRID 1626815 reaction equation
[C:1]([Si:5]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13](I)=[CH:12][C:11]=1[Cl:17])([CH3:7])[CH3:6])([CH3:4])([CH3:3])[CH3:2].[Br:18][C:19]1[CH:24]=[CH:23][C:22](B(O)O)=[CH:21][CH:20]=1>>[Br:18][C:19]1[CH:24]=[CH:23][C:22]([C:13]2[CH:14]=[CH:15][C:10]([CH2:9][O:8][Si:5]([C:1]([CH3:4])([CH3:3])[CH3:2])([CH3:7])[CH3:6])=[C:11]([Cl:17])[CH:12]=2)=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 79599(4-Bromophenyl)boronic acidHCID 68193254HCID 68193254, compound

Product 1

HCID 68193339HCID 68193339, compoundYield 96%

Procedure

In accordance with Example 11-(1), but using tert-butyl[(2-chloro-4-iodobenzyl)oxy]dimethylsilane instead of 4-bromobenzyl bromide, and (4-bromophenyl)boronic acid instead of [3-(hydroxymethyl)phenyl]boronic acid, the title compound (yield 96%) was afforded as a colorless oil.

Sources & evidence

ORD record
ord-5520392aa69c4d8ca32d4cc28fc9f572
Source dataset
uspto-grants-2014_07
Patent number
US08785462B2

Reaction notes

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