4-Bromobenzyl bromide → HCID 68193312, compound

HRID 1626818Notes

Reaction equation

HRID 1626818 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]([O:11][CH2:12][O:13][CH3:14])[CH3:10])=[CH:4][CH:3]=1.[Br:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22]Br)=[CH:18][CH:17]=1>>[Br:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][C:2]2[CH:7]=[CH:6][C:5]([CH2:8][CH:9]([O:11][CH2:12][O:13][CH3:14])[CH3:10])=[CH:4][CH:3]=2)=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 685274-Bromobenzyl bromideHCID 68193311HCID 68193311, compound

Product 1

HCID 68193312HCID 68193312, compound

Procedure

In accordance with Example 19-(2), but using 1-bromo-4-[2-(methoxymethoxy)propyl]benzene instead of tert-butyl 5-(benzyloxy)-2-{[1-(5-bromopyridin-2-yl)piperidin-4-yl]methyl}-6-methylpyrimidine-4-carboxylate, and 1-bromo-4-(bromomethyl)benzene instead of tert-butyl[(4-iodobenzyl)oxy]dimethylsilane, a crude product of 1-bromo-4-{4-[2-(methoxymethoxy)propyl]benzyl}benzene was afforded as a yellow oil.

Sources & evidence

ORD record
ord-8d699f221765479d9fcbf4aa3541d78f
Source dataset
uspto-grants-2014_07
Patent number
US08785462B2

Reaction notes

Loading…