Diethyl Ether → HCID 68193192, compound

Participants

Reaction Steps

Ethyl (4′-bromobiphenyl-4-yl)(difluoro)acetate (1.8 g, 5.1 mmol) obtained in Example 30-(1) was dissolved in tetrahydrofuran (20 mL), and a solution of methyllithium in diethyl ether (1.1 M, 14 mL, 15 mmol) was added under a nitrogen atmosphere at −78° C., followed by stirring at the same temperature for 30 minutes. A saturated aqueous ammonium chloride solution was added to the reaction solution, followed by extraction with ethyl acetate, and subsequently the extract was concentrated under reduced pressure to afford 1-(4′-bromobiphenyl-4-yl)-1,1-difluoroacetone as a pale yellow oil.

Provenance & Evidence