HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-3-fluorobenzeneboronic acid → [(4'-Bromo-3'-fluorobiphenyl-4-yl)methoxy](tert-butyl)dimethylsilane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-3-fluorobenzeneboronic acid | HCID 2773335 | — |
| Reactant | Tert-butyl[(4-iodophenyl)methoxy]dimethylsilane | HCID 10020633 | — |
| Product | [(4'-Bromo-3'-fluorobiphenyl-4-yl)methoxy](tert-butyl)dimethylsilane | HCID 68193222 | 73% |
Reaction Steps
In accordance with Example 4-(2), but using tert-butyl[(4-iodobenzyl)oxy]dimethylsilane instead of tert-butyl[2-(4-iodophenyl)ethoxy]dimethylsilane, and (4-bromo-3-fluorophenyl)boronic acid instead of (4-bromophenyl)boronic acid, the title compound (yield 73%) was afforded as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08785462B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-e9ee7f848d2a4bcc9f35eee40898b271 |
| Source note | uspto-grants-2014_07 |