HCID 68196381, compound → HCID 68196382, compound

Participants

Reaction Steps

Ethyl({[5-(benzyloxy)-2-{(1-[4′-(hydroxymethyl)-3′-isopropenylbiphenyl-4-yl]piperidin-4-yl}methyl)-6-methylpyrimidin-4-yl]carbonyl}amino)acetate (0.094 g, 0.14 mmol) was dissolved in methanol (3 mL), and a palladium-activated carbon ethylenediamine complex (0.090 g) was added, followed by stirring at room temperature for 2 hours under a hydrogen atmosphere. The reaction solution was filtered with celite, the filtrate was concentrated under reduced pressure, and subsequently the resulting residue was purified by chromatography on a silica gel column (Biotage Ltd., elution solvent: dichloromethane/ethyl acetate) to afford the title compound (0.049 g, 0.088 mmol) as a yellowish white amorphous solid (yield 60%).

Provenance & Evidence