HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 57742168, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-(2-Methanesulfonylamino-benzothiazole-6-yl)-propionic acid ethyl ester | HCID 57742149 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 57742168 | HCID 57742168 | — |
Reaction Steps
A mixture of 5 (156 mg, 1 mmol) in THF (10 ml) and H2O (10 ml) is stirred at room temperature. Sodium hydroxide (50 mg, 2.5 mmol) is added to the mixture. The reaction mixture is stirred for 15 h at room temperature. The reaction mixture is acidified to pH 3-4 with acetic acid. Water is added to the mixture and extracted with dichloromethane. The organic layer is dried over magnesium sulfate, filtered and concentrated in vacuo. Yield: quantitative.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08785474B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-aa4472e8675040c99a3a6265becef1cb |
| Source note | uspto-grants-2014_07 |