Phosphoric Acid → HCID 54674530, compound

Participants

Reaction Steps

Free base (R)-3-amino-1-((3aS,6aS)-5-(2-fluoro-2-methylpropionyl)-hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one compound 7 (100 mg, 0.24 mmol) obtained from example 7 was dissolved in ethanol (0.5 mL), added dropwise into phosphoric acid (24 mg, 0.24 mmol) in ethanol solution (1 mL), stirred until precipitation of white solid, filtered to give (R)-3-amino-1-((3aS,6aS)-5-(2-fluoro-2-methylpropionyl)-hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one phosphate compound 10 (84 mg, 84%) as white powder. MS m/z (ESI): 416.4 (M+1), 438.2 (M+Na). 1H NMR (D2O, 400 MHz): δ 1.62 (m, 6H), 1.96 (m, 1H), 2.20 (m, 1H), 2.78-2.91 (m, 2H), 3.05-3.30 (m, 3H), 3.42-3.83 (m, 6H), 3.96 (m, 2H), 7.20 (m, 1H), 7.35 (m, 1H).

Provenance & Evidence